Saturday, September 17, 2011

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Opiods in acute pulmonary edema

The use of I.V morphine in dyspnea from pulmonary edema due to left ventricular failure produces remarkable relief. The proposed mechanisms include: 
1) reduced anxiety ( decreased perception of shortness of breath ), 
2) reduced cardiac preload ( reduced venous tone ) and 
3) decreased cardiac afterload (decreased peripheral resistance ). 

However frusemide remains the treatment of choice. Side effect is respiratory depression at a higher dosage which occurs because of inhibition of the brainstem respiratory mechanism.


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