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Showing posts with the label Rheumatology

Calcinosis cutis

Colchicine - complete information

Introduction: Colchicine is an alkaloid isolated from the autumn crocus, Colchicum autumnale. It is actually present in the corm of the plant, the underground swollen part of the stem. Pharmacokinetics: Colchicine is absorbed readily when taken in orally. It reaches peak plasma levels within 2 hours.  It has a serum half-life of 9 hours.  Colchicine is partially deacetylated in the liver and the unchanged drug and its metabolites are excreted in the bile and undergo intestinal reabsorption. Colchicine is found in high concentrations in leucocytes, kidneys, the liver and spleen. Most of the drug is excreted in the feces but 10 to 20% is excreted in the urine and this proportion rises in patients with liver disorders. For patients with creatinine clearance of < 50 mL/min, colchicine must be avoided or used at a lower dose. Colchicine is also distributed into breast milk. Pharmacodynamics: Colchicine relieves the pain and inflammation of gouty arthritis in 12-24 hou