Sunday, August 5, 2012

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Insulin - Structure

Insulin is a protein hormone. It was the first protein to be shown to have a precisely defined amino acid sequence. This work was done by Federick Sanger in 1953. 
As shown above in two colours, the insulin molecule consists of 2 peptide chains. 
a) The blue coloured chain is the A chain. It has 21 amino acids and a sisulphide bond within itself. 
b) The yellow colour represents the B chain. It is larger with 30 amino acids. 
Both chains are connected by 2 disulphide bridges. 
Porcine and bovine insulins differ from human insulin at 1 and 3 positions of the amino acids respectively. 

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