Wednesday, September 21, 2011

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Diabetes insipidus - effect of desmopressin

This is a continuation of the main article Diabetes insipidus. It shows the effect of desmopressin in a case of central D.I.

The changes seen are:
1) decrease in urine output,
2) increase in urine osmolarity,
3) decrease in plasma osmolarity and
4) slight increase in body weight.

Desmopressin is 12 times more potent antidiuretic than ADH. It has a duration of action of around 8 hours and thus can be given in 3 divided doses per day. The intranasal route is preferred though the bioavailability is only 10-20%. Treatment is life long.


  1. Desmopressin (trade names DDAVP, DesmoMelt, Minirin) is a synthetic replacement for vasopressin, the hormone that reduces urine production. Apart from its increasing effect on water resorption by the kidneys, it raises plasma levels of von Willebrand factor and factor VIII. Desmopressin