Thursday, May 19, 2011

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Red blood cell formation


Under certain specific stimuli, pluripotent stem cells form CFU-E i.e Colony Forming Units - Erythrocytes. These cause production of cells that are the first to belong to the RBC series, proerythroblast. The next generation is called basophilic erythroblast because it stains with basic dyes. 


As the genesis continues, hemoglobin concentration increases while the nucleus condenses to a very small size. The remnant of the nucleus is either absorbed or extruded out of the cell. Endoplasmic reticulum is also absorbed. The cell is now called a reticulocyte


The reticulocyte has some basophilic remnants of Golgi apparatus, mitochondria and other organelles. During this reticulocyte stage, the cells pass from the bone marrow into the blood capillaries by diapedesis i.e squeezing through the pores of the capillary membrane.


The remaining basophilic material in the reticulocyte normally disappears within 1 to 2 days, and the
cell is then a mature erythrocyte.

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