Medicine Hack

In this condition, there is a delay in conduction between the atria and the ventricles. There is a prolongation of the PR interval to more than 200 ms. i.e > 5 small squares on a usual 25 mm/s ECG tracing. The normal duration for PR interval is 120 - 200 ms. A QRS complex follows each P wave and the PR interval is relatively constant from beat to beat. The pathology is usually due to a delay within the AV node if we have a normal QRS complex. But if the QRS complex is wide, the problem is more distal.

Ginkgo extracts are derived from the leaf of the ginkgo plant. It is the most commonly purchased herbal remedy in the USA. It is believed to help in non-dementia related memory problems, Alzheimer's disease, vertigo and even peripheral vascular diseases. There is documented evidence that ginkgo inhibits platelet activating factor and hence it is useful to decrease blood viscosity. The dosage to treat claudication is 40-80 mg three times daily. Caution must be taken if patient is taking heparin, warfarin, clopidogrel or aspirin as there may be increased chances of bleeding.

The 6 P's are: 1) Pain, 2) Pallor, 3) Pulselessness, 4) Paralysis, 5) Paraesthesia, 6) Perishingly cold.

a.c - ante cibum i.e. before food. p.c - post cibum (after food). o.m - omni mane (every morning). o.n - omni nocte (every night). o.d - omni die (once daily). b.d - bis die (twice daily). t.i.d - ter in die ( three times daily). t.d.s - ter die sumendum (to be taken three times daily). q.d.s - quater die sumendum (to be taken four times daily). p.r.n - pro re nata (when required). stat - immediately.

The central dogma for molecular biology refers to the flow of information from DNA to RNA to proteins. Nucleic acids are required for the storage and expression of genetic information. There are two chemically distinct types of nucleic acids: 1) deoxyribonucleic acid (DNA) and 2) ribonucleic acid (RNA). DNA is the store of genetic information and is present not only in chromosomes in the nucleus of eukaryotic organisms, but also in mitochondria and the chloroplasts of plants. Prokaryotic cells, which lack nuclei, have a single chromosome, but may also contain nonchromosomal DNA in the form of plasmids. The genetic information found in DNA is copied and transmitted to daughter cells through DNA replication. The DNA contained in a fertilized egg encodes the information that directs the development of an organism. This development may involve the production of billions of cells. Each cell is specialized, expressing only those functions that are required for it to perform its r

The intensity of a systolic murmur is not always proportional to the hemodynamic disturbance. Yet murmurs are classified according to the loudness. Freeman and Levine were the first to introduce a numerical scale for grading heart murmur intensity in 1933. This grading is still used but with some modifications. Grade 1 - so faint that it can be heard only with special effort. Grade 2 - faint but can be heard easily. Grade 3 - moderately loud but no thrill. Grade 4 - very loud and thrill may be there. Grade 5 - extremely loud and can be heard if only the edge of stethoscope is in contact with skin. Grade 6 - exceptionally loud and can be heard with stethoscope just removed from skin contact. Keren, Tereschuk and Luan suggested that we can use heart sounds as an internal reference to differentiate between grades 1-3, the only limitation of the study being a small sample used. The grading is the same as above but. . . Grade 1 - clearly softer than the heart sounds. Grade 2 -

As soon as a diagnosis of VTE / PE is strongly suspected, anticoagulant therapy should be started unless there are contraindications. Parenteral drugs like unfractionated heparin (standard heparin) and low molecular weight heparin (lovenox) are started and therapy shifted to a long term stable vitamin K antagonist like warfarin. Unfractionated heparin The anticoagulant action is by binding to and accelerating the activity of antithrombin III. This inactivates thrombin, factor IXa and Xa and thus prevents further clot formation. The classical regimen for the dosage is a loading dose of 5000 - 10000 units followed by a continuous infusion of 1000 - 1500 units/hour. Unfortunately we all do not have the same weight. So, a more appropriate dosage is a loading dose of 80 units/kg and a continuous infusion of 18 units/kg/hr. The aim is to achieve a target activated partial thromboplastin time (aPTT) aka partial thromboplastin time with kaolin (PTTK) of 2-3 times the normal laboratory val