Medicine Hack

It is a nice diagramatic representation of how the content of the diet of individuals varies with increase their income. This clearly causes an increase in the risk for cardiovascular diseases. As the income increases, there is a drastic increase in the intake of saturated animal fats and hydrogenated vegetable fats both of which contain atherogenic trans fatty acid. Simple carbohydrates are taken in more and vegetables are less eaten.

Life expectancy in the United States has changed from 48.3 yr in 1900 to 78.4 yr in 2011. That of the United Kingdom from 46.4 yr to 78.0 yr. Both countries have passed through the age of pestilence and famine, the age of pandemics, the age of degenerative diseases to finally enter into the age of inactivity and obesity.

Under certain specific stimuli, pluripotent stem cells form CFU-E i.e Colony Forming Units - Erythrocytes. These cause production of cells that are the first to belong to the RBC series, proerythroblast . The next generation is called basophilic erythroblast because it stains with basic dyes.  As the genesis continues, hemoglobin concentration increases while the nucleus condenses to a very small size. The remnant of the nucleus is either absorbed or extruded out of the cell. Endoplasmic reticulum is also absorbed. The cell is now called a reticulocyte .  The reticulocyte has some basophilic remnants of Golgi apparatus, mitochondria and other organelles. During this reticulocyte stage, the cells pass from the bone marrow into the blood capillaries by diapedesis i.e squeezing through the pores of the capillary membrane. The remaining basophilic material in the reticulocyte normally disappears within 1 to 2 days, and the cell is then a mature erythrocyte .

T ransposition of the great arteries T otal anomalous pulmonary venous return T runcus arteriosus T ricuspid atresia T etralogy of Fallot E bstein's anomaly E isenmenger physiology Critical pulmonary stenosis or atresia Functionally single ventricle Note there are 5 Ts and 2 Es.

Angiotensinogen, the precursor of all angiotensin peptides, is synthesized by the liver. In the circulation it is cleaved by renin, an acid protease, which is secreted into the lumen of renal afferent arterioles by juxtaglomerular cells. Renin is synthesized as a large preprohormone called as preprorenin. It is then cleaved to prorenin and eventually to renin. Prorenin is also secreted by other organs like ovaries. But, conversion to renin is almost exclusively the job of the kidney. This has been seen after nephrectomies. The level of prorenin in the blood remains more or less the same while that of active renin falls to almost zero. Renin cleaves angiotensinogen, thereby forming angiotensin I. In turn, angiotensin I is cleaved by angiotensin-converting enzyme (ACE), an enzyme bound to the membrane of endothelial cells, to form angiotensin II. Much of the conversion occurs as blood passes through the lungs but it also occurs elsewhere in the other parts of the body too. In