Medicine Hack

COPD exacerbation: Definition: Exacerbation of COPD is defined as an acute episode, characterized by the worsening of the patient’s respiratory symptoms that is beyond normal daily variations and that will eventually lead to a change in his medications. Those having 2 or more exacerbations per year are known as “frequent exacerbators”. Precipitating factors: 1) Respiratory tract infections – viral or bacterial. Most common cause. There may be an increased bacterial burden in the lower airways or new strains of bacteria are acquired during an exacerbation. Commonly implicated viruses include rhinovirus, respiratory syncytial virus, coronavirus and influenza virus. 2) Air pollution. 3) Interruption of maintenance therapy. 4) Unknown causes – 30% cases. Diagnosis: Diagnosis should be made clinically whereby the patient complains of an acute aggravation of his symptoms out of proportion to his day to day variations.  Assessment: Medical history: 1) Se

Definition: Mild to moderate nausea and vomiting are seen commonly until approximately 16 weeks in most pregnant ladies. Although nausea and vomiting tend to be worse in the morning, thus erroneously termed morning sickness, they frequently continue throughout the day. In some cases, however, it is severe and unresponsive to simple dietary modification and antiemetics. Hyperemesis gravidarum is defined as vomiting sufficiently severe to produce weight loss, dehydration, alkalosis from loss of hydrochloric acid and hypokalemia. Rarely, acidosis from partial starvation and transient hepatic dysfunction develop. Modified PUQE scoring index  (Pregnancy-Unique Quantification of Emesis and Nausea) can be used to quantify the severity of nausea and vomiting.  Epidemiology: There appears to be an ethnic or familial predilection. The hospitalization rate for hyperemesis is around 0.5 to 0.8%. Hospitalization is less common in obese women. In women hospitalized in a previous pregnan

(A) Enzyme–substrate complex;  (B) a competitive inhibitor binds at the active site and thus prevents the substrate from binding;  (C) an uncompetitive inhibitor binds only to the enzyme–substrate complex;  (D) a noncompetitive inhibitor does not prevent the substrate from binding.

Pericardium The pericardium is a fibroserous sac surrounding the heart and the roots of the great vessels. It consists of two components,  1) the fibrous pericardium and  2) the serous pericardium. The fibrous pericardium is a tough connective tissue outer layer that defines the boundaries of the middle mediastinum.  The serous pericardium is thin and consists of two parts: 1) The parietal layer lines the inner surface of the fibrous. 2) The visceral layer adheres to the heart and forms its outer covering. The parietal and visceral layers of serous pericardium are continuous at the roots of the great vessels. The narrow space created between the two layers of serous pericardium, containing a small amount of fluid, is the pericardial cavity. This is pictured in the diagram above as a fist in a filled balloon. This potential space allows for the relatively uninhibited movement of the heart. Fibrous pericardium The fibrous pericardium is a cone-shape